Phospho- and total p53 assays for monitoring cellular response to DNA damage
These cell-based assays are designed to monitor the modulation of total and phosphorylated p53 (Serine 15).
Buffer compatibility means you can use both assays on the same lysate (in parallel) to normalize your results.
Due to its tumor suppressor action in many tumor types, P53 has been described as "the guardian of the genome" because of its role in safeguarding genome integrity. P53 has many anticancer function mechanisms, thereby inducing apoptosis, senescence, cell cycle regulation, growth arrest, genomic stability, angiogenesis inhibition, and metabolism changes by regulating the expression of various target genes.