Phospho- and total FGFR2 assays for the pharmacological study of FGF binding in cancer and CNS research
FGFR2 (also called CD332) is a receptor for FGF (fibroblast growth factor). Like all growth factor receptors, ligand binding induces receptor dimerization / autophosphorylation ans subsequent signaling through MAPK and Pi3K/Akt pathways. Mutations in FGFR2 have been associated with cancer (breast, melanoma) and abnormal bone development (cranosynostosis syndromes).
Our offer includes cell-based phospho FGFR2 (Tyr653/654) assay to monitor receptor activation and total FGFR2 to normalize against steady state expression.