Small molecule labeling services

We label many kind of materials!

We label small molecules, nucleic acids…

In the field of drug discovery, researchers are constantly seeking small molecules with therapeutic applications.
Every scientist knows that small molecule labeling often requires a highly specific chemical approach and purification process.
The chemistry team at Cisbio has unmatched experience in small molecule bioconjugation.

A solid experience on custom labeling techniques

Our offer includes:

  • Labeling of small molecules with Europium & Terbium cryptates:
    • Aromatics & heterocycle compounds
    • Steroids
    • Saccharides
    • Nucleosides
  • Derivatization of pharmacophore
  • Introduction of linkers prior to labeling, to retain activity
  • Reproduction of a synthesis described in the literature
A solid experience on custom labeling techniques
Cisbio excels in services. Our expertise is backed by our comprehensive understanding of chemistry and a commitment to R&D investment, as demonstrated by over 30 years in the life science & drug discovery fields.
Pharmaceutical companies, Biotechs, and academic laboratories looking to outsource their small molecule labeling projects often find in Cisbio the ideal partner. Let’s explain why.

Our chemists are our greatest asset

Scientists in the Cisbio Chemistry Laboratories have very special researcher-developer profiles, a double competence from which your project is now able to benefit in many ways. Selecting Cisbio for your small molecule work is the promise of bringing in a team with unmatched expertise in chemistry.

  • Highly trained chemists (at PhD., Master’s, and Technician levels) with 10 to 20 years of experience
  • Access to scientists able to combine their understanding of the research approach with the reality of industrial obligations
  • Absence of employee turnover ensures institutional knowledge retention
  • Experience gained from both internal and external projects, through a large collaboration network in academia and industry
  • Experience gained from long-standing relationships with key opinion leaders in chemistry like J. M. Lehn (Nobel Prize), David Parker (Durham University), and Marcel Hibert (Strasbourg University)
  • Your material receives the same attention and discerning synthesis techniques as the material Cisbio uses in its own catalogue products
Our chemists are our greatest assets

Our publications, our credibility

Cisbio’s chemists devote part of their time to synthetizing different molecules, in particular the fluorophores vital to the Cisbio offer, and to looking after clients’ custom projects. The remainder of the time is spent on pure chemistry research, advancing their knowledge and developing new processes and techniques, thus pushing back the boundaries of the field of chemistry. Below is selection of their work:

Publications

The Journal of Organic Chemistry
Arán, V.J., Kumar, M., Molina, J., Lamarque, L., Navarro, P., García-España, E., Ramirez, J.A., Luis, S.V. and Escuder, B., 1999. Synthesis and protonation behavior of 26-membered oxaaza and polyaza macrocycles containing two heteroaromatic units of 3, 5-disubstituted pyrazole or 1-benzylpyrazole. A potentiometric and 1H and 13C NMR study. The Journal of Organic Chemistry, 64(17), pp.6135-6146.

Chemical Communications
Walton, J.W., Bourdolle, A., Butler, S.J., Soulie, M., Delbianco, M., McMahon, B.K., Pal, R., Puschmann, H., Zwier, J.M., Lamarque, L. and Maury, O., 2013. Very bright europium complexes that stain cellular mitochondria. Chemical Communications, 49(16), pp.1600-1602.

The Journal of American Chemical Society
Miranda, C., Escartí, F., Lamarque, L., Yunta, M.J., Navarro, P., García-España, E. and Jimeno, M.L., 2004. New 1 H-pyrazole-containing polyamine receptors able to complex l-glutamate in water at physiological pH values. Journal of the American Chemical Society, 126(3), pp.823-833.

Chemical Sciences
Butler, S.J., Lamarque, L., Pal, R. and Parker, D., 2014. EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging. Chemical Science, 5(5), pp.1750-1756.Nature Chemical Biology Albizu, L., Cottet, M., Kralikova, M., Stoev, S., Seyer, R., Brabet, I., Roux, T., Bazin, H., Bourrier, E., Lamarque, L. and Breton, C., 2010. Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nature chemical biology, 6(8), p.587.

Inorganic chemistry
Bourdolle, Adrien, et al. “Modulating the photophysical properties of azamacrocyclic europium complexes with charge-transfer antenna chromophores.” Inorganic chemistry50.11 (2011): 4987-4999

Our molecules speak for our expertise

The synthesis of a europium tris-bipyridine cryptate (Eu(K)) is no walk in the park to say the least. Europium Cryptate is one of the complex molecules that Cisbio chemists synthesize on a monthly basis to supply Cisbio assay development scientists with enough material to create new assays and reagents.

Eu(K) is a testament to the skills of our chemists.

Europimum cryptate

Flexibility and customer support

At Cisbio, we understand that there is no single solution for the synthesis of your ideal molecule, and that every project brings its own set of challenges. We also understand that every project is unique and will not fit a template.

Do you have a question about your final product? Do you need to discuss what the numbers on the report mean? Automated phone systems infuriate you? Cisbio guarantees direct access to the scientist who performed your labeling. We do not use automated phone systems or a complex directory. Simply talk to the right person, right away.

With Cisbio, you will receive a complimentary proposal and customized approach to your project from a dedicated chemist.

Customer support

A clear and straightforward process

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*(Electronic-lab-book and database located and secured on our headquarters site)

Deliverables include:

  • To supply a compound with high purity level
  • To package exact quantities based on UV quantification
  • To determine a process to solubilize the conjugated molecule
  • To supply safety documents (MSDS files)
  • To supply an Analysis certificate including HPLC / UPLC traces, UV and MS spectra.
  • To supply HRMS analysis on request
  • Access to NMR facilities to confirm structures (if scale and type of molecule are compatible with such analysis)
  • Vial label with solvent- and temperature-resistant inks

Next-generation facilities

The chemistry labs are located near Avignon, France, and are equipped with the latest technology. Cisbio’s labs and scientists have the latest equipment, ready to deliver the best possible synthetic chemistry service and the most precise analytical reporting.
Equipment includes:

  • Several fume hoods
  • Rotating evaporators under fume hoods, ensuring a healthy laboratory atmosphere
  • UPLC MS for reaction monitoring
  • Semi preparative HPLC (purification of small quantities)
  • Preparative HPLC (up to 100 mg)
  • Automatized chromatography purification (Reveleris)
  • Large set of HPLC columns
  • Speed vac for solvent removal
  • Lyophilizer
  • Microwave reactor (CEM) to speed up reactions and reduce side reactions
  • Mass spectrometer (simple quadripole) coupled to UPLC in a safe room away from solvent
  • Large number of chemical reagents stored in safe room site
  • Reaction under inert atmosphere (argon line)
  • Reaction at low temperature
  • Hydrogenation reactor facilities
  • Reaction under pressure with steel reactor
  • UV spectrometer
Our chemists are our greatest assets

 

Stéphanie-Soldevila

I label your small molecules to make them shine brightly in your research!

Stéphanie

Laurent Lamarque

I create fluorescent dyes to unleash your assays’ performance!

Laurent

Emmanuel Bourrier

I help create the chemical tools you need to stay focused on your assays.

Emmanuel

Meet the whole custom solution team

Take the tour!

Explore our US and Europe labs to check our latest equipment, and look around our chemistry lab where small molecule labeling magic occurs!

Visit our labs

 

 

Ready to discuss your project?

Cisbio’s knowledgeable team of scientists are ready to help you.
No matter what the inquiry, our commitment to exceptional service ensures that we will provide you an optimal solution.

Contact us

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