Tag-lite CXCR4 stably expressing cells
Chemokine CXCR4R expressing cells labeled with Terbium
- Fully functional cell line
- Transient expression
- Ready for binding
CXCR4 is a receptor for the C-X-C chemokine CXCL12/SDF-1. Compelling evidences suggest that CXCR4 is nvolved in hematopoiesis and in cardiac ventricular septum formation. The receptor also plays an essential role in vascularization of the gastrointestinal tract.
CXCR4 acts as a coreceptor for human immunodeficiency virus-1/HIV-1. Cells expressing the CXCR4 receptor are provided pre-labeled with Terbium, and can be used to conduct receptor binding studies on the aforementioned receptor.
Examples of data obtained using Chemokine CXCR4 labeled cells and their matching fluorescent ligand (L0012RED). AMD-3100 was used as reference ligand. Results may vary from one HTRF® compatible reader to another.
Tag-lite assay read on Synergy (BioTek) - Application Notes
In collaboration with Boehringer Ingelheim - Scientific Presentations
In collaboration with Bayer - Scientific Presentations
Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
In collaboration with BioTek - Posters
Determination of association (kon) and dissociation (koff) rates constants using the Tag-lite platform
Challenge the limits of binding kinetics studies - Application Notes
Featuring a panel of experts - Videos
The gold standard technology for receptor binding studies - Videos
A look at the kinetics of cAMP production in cells - Application Notes