APP (BACE1 substrate)
Beta-secretase (BACE1) is an enzyme which cleaves amyloid precursor protein (APP) to produce the amyloid ß42 peptide, responsible for insoluble amyloid plaques in Alzheimer's disease (AD).
APP substrate, used with HTRF APP substrate labeled with both biotin and Eu3+ Cryptate, enables the study of High enzymatic Km to monitor beta-secretase (BACE1) activity.
Easy pharmacological characterization of PPI modulators. - Technical Notes
Deciphering low- and high affinity interactions - Application Notes
Monitoring nuclear receptor binding with HTRF assays - Application Notes
Challenge large complexes with HTRF assays - Application Notes