It is reported that about 40 million people around the globe are living with Dementia, and this number is likely to at least double by 2050.
The study of all the neurodegenerative disorders that trigger the full deterioration of intellectual capacities, and their associated symptoms, represents one of the greatest challenges faced by researchers today.
A characteristic of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Spinal Muscular Atrophy, Friedreich’s ataxia, Frontotemporal dementia and amyotrophic lateral sclerosis (ALS), is the dysfunction in protein homeostasis and/or the aggregation of some proteins.
Cisbio has developed a panel of ready-to-use assays to monitor biomarkers involved in challenging neurodegenerative diseases.
Our assays to investigate Alzheimer and Parkinson diseases
HTRF assays Click to view product
Spinal muscular atrophy
Neuroinflammation mediated by glial cells (microglia & astrocytes) is recognized as an important mechanism regulating brain function and dysfunction, thus contributing to the onset of neurodegenerative disease.
Cisbio offers a wide range of high quality cytokine, chemokine, and biomarker assays to monitor neuroinflammatory processes.
G protein-coupled receptors (GPCRs) are the most widely-investigated targets in the treatment of neurological and psychiatric disorders, since these receptors are stimulated by multiple neurotransmitters.
Cisbio offers an effective and competitive alternative to radioligand binding assays for the identification of new psychoactive drugs, thanks to our Tag-lite® technological platform.
Neuronal cell signaling pathways govern interactions among different types of cells in the brain, including neuronal, glial, and vascular, thus contributing to the homeostasis of normal brain function. Any imbalance or signaling dysfunction can contribute to the onset of disease.
Cisbio offers a line of cell-based HTRF® pathway assays for investigating signaling activity by detecting phosphorylated/total proteins in a cellular environment. These assays provide an ideal functional pathway signaling solution for CNS researchers, providing them with a rapid, streamlined alternative to more conventional technologies, such as Western Blot or ELISA.