Neuroscience

It is reported that about 40 million people around the globe are living with Dementia, and this number is likely to at least double by 2050.
The study of all the neurodegenerative disorders that trigger the full deterioration of intellectual capacities, and their associated symptoms, represents one of the greatest challenges faced by researchers today.

hand dude
hand fam
hand meclunette
black-hnd black

Neurodegenerative Markers

A characteristic of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Spinal Muscular Atrophy, Friedreich’s ataxia, Frontotemporal dementia and amyotrophic lateral sclerosis (ALS), is the dysfunction in protein homeostasis and/or the aggregation of some proteins.

Cisbio has developed a panel of ready-to-use assays to monitor biomarkers involved in challenging neurodegenerative diseases.

Our assays to investigate Alzheimer and Parkinson diseases

Legend, assay available   HTRF assays   Click to view product

Spinal muscular atrophy

Friedreich’s ataxia

Frontotemporal dementia

Neuroinflammation

Neuroinflammation mediated by glial cells (microglia & astrocytes) is recognized as an important mechanism regulating brain function and dysfunction, thus contributing to the onset of neurodegenerative disease.

Cisbio offers a wide range of high quality cytokine, chemokine, and biomarker assays to monitor neuroinflammatory processes.

Psychiatric disorders

G protein-coupled receptors (GPCRs) are the most widely-investigated targets in the treatment of neurological and psychiatric disorders, since these receptors are stimulated by multiple neurotransmitters.

Cisbio offers an effective and competitive alternative to radioligand binding assays for the identification of new psychoactive drugs, thanks to our Tag-lite® technological platform.

Cell signaling

Neuronal cell signaling pathways govern interactions among different types of cells in the brain, including neuronal, glial, and vascular, thus contributing to the homeostasis of normal brain function. Any imbalance or signaling dysfunction can contribute to the onset of disease.

Cisbio offers a line of cell-based HTRF® pathway assays for investigating signaling activity by detecting phosphorylated/total proteins in a cellular environment. These assays provide an ideal functional pathway signaling solution for CNS researchers, providing them with a rapid, streamlined alternative to more conventional technologies, such as Western Blot or ELISA.

Cell signaling competitive landscape
HTRF, Western Blot, ELISA assay procedures comparison