Bradykinin B2R expressing cells labeled with Terbium
Tag-lite cells expressing the Bradykinin B2 receptor with Terbium
Bradykinin receptor has two known isoforms bradykinin type 1 and 2 receptors. Both receptors are GPCR but mediate different actions. While B1R signaling promotes local tissue inflammation by recruiting neutrophils, B2R signaling is believed to downregulate the proliferation and growth of cells in VSMC and cardiomyocytes.
Cells expressing the B1 receptor are provided pre-labeled with Terbium, and can be used to conduct receptor binding studies on the aforementioned receptor.
Examples of data obtained using Bradykinin B1 labeled cells and their matching fluorescent ligand (L0016RED). [Des-Arg 10] Kallidin was used as reference ligand. Results may vary from one HTRF® compatible reader to another.
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