Bradykinin B2R expressing cells labeled with Terbium
- Fully functional cell line
- Transient expression
- Ready for binding
Bradykinin receptor has two known isoforms bradykinin type 1 and 2 receptors. Both receptors are GPCR but mediate different actions. While B1R signaling promotes local tissue inflammation by recruiting neutrophils, B2R signaling is believed to downregulate the proliferation and growth of cells in VSMC and cardiomyocytes.
Cells expressing the B2 receptor are provided pre-labeled with Terbium, and can be used to conduct receptor binding studies on the aforementioned receptor.
- PRE-LABELED WITH TERBIUM
- FROZEN CELLS, READY TO BE USED
- CELLS/LIGAND VALIDATED FOR BINDING
Examples of data obtained using Bradykinin B2 labeled cells and their matching fluorescent ligand (L0017RED). HOE 140 was used as reference ligand. Results may vary from one HTRF® compatible reader to another.
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Determination of association (kon) and dissociation (koff) rates constants using the Tag-lite platform
Challenge the limits of binding kinetics studies - Application Notes
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The gold standard technology for receptor binding studies - Videos
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