The use of HTRF in biologics discovery

Liz England

2013

MedImmune, Cambridge, UK

5th HTRF Symposium, Avignon, France

Homogeneous Time Resolved Fluorescence (HTRF®) assay technology is widely used at MedImmune for high throughput biochemical screening to identify biologic candidate drugs. This technology has many benefits over traditional plate based assay formats due to the homogeneous nature of the assays, which enables increased throughput, rapid assay development and reduced hands on laboratory time. The ability to establish robust, sensitive HTRF® assays in a variety of configurations using toolbox reagents has provided the flexibility required to screen and characterise lead biologics. This presentation will outline the application of HTRF® technology at MedImmune for the isolation, optimisation and characterisation of biologic candidate drugs.

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