Immune checkpoint assay to identify adenosine A2A receptor checkpoint inhibitors
Extracellular adenosine, present in the tumor micro-environment (TME), has been identified as a fundamental element in immune response regulation.
Cancer cell proliferation generates local hypoxia in the TME, leading to secretion of adenosine by the surrounding cells. In this context, the interaction between adenosine and its A2A receptor can be stimulatory or inhibitory, depending on the state of the TME and the immune system.
Our range offers everything you need to set up your cell-based binding assay: labelled reference lignad, labelled frozen cells, and buffers. They can be used to set up saturation biding assays (Kd) or competitive binding assays (Ki).