Aldosterone is a steroid hormone (mineral corticoid) produced by the adrenal gland, that is involved in sodium and potassium metabolism. In the body, cholesterol is successively transformed into pregnenolone, progesterone, deoxycorticosterone and corticosterone. The conversion of corticosterone into Aldosterone is catalysed by Aldosterone synthase for pancreatic ß-cell supernatants and serum samples. Based on our patented HTRF® technology, the Aldosterone kit is a highly sensitive assay for quantifying aldosterone synthase activity.
Our Technology HTRF
HTRF® technology principle:
Truly homogeneous functional assays
FRET (Fluorescence Resonance Energy Transfer) is based on the transfer of energy between two fluorophores – a donor and an acceptor – when in close proximity. Molecular interactions between biomolecules can be assessed by coupling each partner with a fluorescent label and by detecting the level of energy transfer.