Use a rapid, sensitive and cost effective alternative to ELISA
HTRF BACE1 assay provides a sensitive and efficient method for screening BACE1 (or human b-secretase) inhibitors in a high-throughput manner. This assay uses a new HTRF APP swedish peptide substrate.
BACE1 cleaves amyloid precursor protein (APP) to produce the amyloid β42 peptide which is responsible for insoluble amyloid plaques of Alzheimer's disease (AD). The development of specific BACE-1 inhibitors has therefore become an attractive approach for treatment of AD.