HIF-1α assay for measuring this master transcriptional regulator of cellular and developmental response to hypoxia
HIF-1α is one of the 2 subunits of the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF1 acts as a master regulator of cellular and systemic response to hypoxia by activating the translation of genes involved in energy metabolism, angiogenesis, and apoptosis, among others. High levels of HIF 1 have been associated with aggressive tumor progression, and thus it has been investigated as a predictive and prognostic marker for resistance to radiation treatment and chemotherapy.
HIF-1α is also strongly linked to diabetes through its involvement in the glucose uptake of target cells. It has also been implicated in diabetes complications, for example diabetic nephropathy or diabetic wound repair.