Orexin OX1 and OX2R fluorescent probe
Tag-lite Orexin OX1 & OX2 receptors fluorescent probe
Two orexin receptors, OX1R and OX2R, also named HCTR1 and HCTR2, have been characterized to date. Studies show that both OX1R and OX2R play a broad regulatory role in the central nervous system and could regulate feeding, sleep, emotion, and reward functions.
Cells expressing the OX2 receptor are provided pre-labeled with Terbium, and can be used to conduct receptor binding studies on the aforementioned receptor.
Examples of data obtained using Orexin OX2 labeled cells and their matching fluorescent ligand (L0025RED). Orexin A was used as reference ligand. Results may vary from one HTRF® compatible reader to another.
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The gold standard technology for receptor binding studies - Videos
A look at the kinetics of cAMP production in cells - Application Notes
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How to revolutionize your kinetic binding demonstration with HTRF kinase binding platform assays - Application Notes