SARS-CoV-2 S1/ACE2 binding kit HTRF®
The SARS-CoV-2 S1/ACE2 binding kit is designed to identify inhibitor or S1/ACE2 interactions.
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No-wash
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All inclusive kit
Overview
ACE2 is a human cell surface receptor that has been identified as the main point of entry for SARS-CoV-2 virions, which match and bind ACE2 with their own viral Spike protein S1 subunits. This interaction is therefore a key target in COVID-19 therapeutic research, as its inhibitors may yield a protective effect by preventing SARS-CoV-2 entry into cells. For this reason, protein-protein interaction assays suitable for ACE2-Spike inhibitor screening are relevant to current research.
Benefits
- SARS-COV-2 INFECTION DRUG DISCOVERY
- KD DETERMINATION
Validation of S1/ACE2 binding kit with unlabeled S1 and ACE2 proteins
4 µL of the unlabeled S1 or ACE2 proteins were dispensed into a 384 LV volume plate. 8 µL of labeled S1 with d2 and 8µl of ACE2 labeled with cryptate were added to the same wells. The plate was incubated 24h at +4°C before reading on a special time-resolved fluorescence reader.
Validation of S1/ACE2 binding kit with neutralizing Ab control
4 µL of the neutralizing Ab were added to a 384 LV volume plate. 8 µL of S1 labeled with d2 and 8µl of ACE2 labeled with cryptate were added to the same wells. The plate was incubated 24h at +4°C before reading on a special time-resolved fluorescence reader.
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HTRF addresses large protein-protein interaction complexes
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Product Insert S1/ACE2 binding kit / 64BDS1PEG-64BDS1PEH
64BDS1PEG-64BDS1PEH - Product Insert
Safety Data Sheet (DEU) S1/ACE2 binding kit / 64BDS1PEG
64BDS1PEG - Safety Data Sheet
Safety Data Sheet (ELL) S1/ACE2 binding kit / 64BDS1PEG
64BDS1PEG - Safety Data Sheet
Safety Data Sheet (FRA-FR) S1/ACE2 binding kit / 64BDS1PEG
64BDS1PEG - Safety Data Sheet
Safety Data Sheet (ITA) S1/ACE2 binding kit / 64BDS1PEG
64BDS1PEG - Safety Data Sheet
Safety Data Sheet (SPA) S1/ACE2 binding kit / 64BDS1PEG
64BDS1PEG - Safety Data Sheet
Safety Data Sheet (ENG-GB) S1/ACE2 binding kit / 64BDS1PEG
64BDS1PEG - Safety Data Sheet
Safety Data Sheet (ENG-US) S1/ACE2 binding kit / 64BDS1PEG
64BDS1PEG - Safety Data Sheet
Safety Data Sheet (DEU) S1/ACE2 binding kit / 64BDS1PEH
64BDS1PEH - Safety Data Sheet
Safety Data Sheet (ELL) S1/ACE2 binding kit / 64BDS1PEH
64BDS1PEH - Safety Data Sheet
Safety Data Sheet (FRA-FR) S1/ACE2 binding kit / 64BDS1PEH
64BDS1PEH - Safety Data Sheet
Safety Data Sheet (ITA) S1/ACE2 binding kit / 64BDS1PEH
64BDS1PEH - Safety Data Sheet
Safety Data Sheet (SPA) S1/ACE2 binding kit / 64BDS1PEH
64BDS1PEH - Safety Data Sheet
Safety Data Sheet (ENG-GB) S1/ACE2 binding kit / 64BDS1PEH
64BDS1PEH - Safety Data Sheet
Safety Data Sheet (ENG-US) S1/ACE2 binding kit / 64BDS1PEH
64BDS1PEH - Safety Data Sheet
Plate Reader Requirement
Choosing the right microplate reader ensures you’ll get an optimal readout. Discover our high performance reader, or verify if your lab equipment is going to be compatible with this detection technology.
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